Author: Malik, Shahana S.; Azem-e-Zahra, Syeda; Kim, Kyung Mo; Caetano-Anollés, Gustavo; Nasir, Arshan
Title: Do Viruses Exchange Genes across Superkingdoms of Life? Document date: 2017_10_31
ID: 12dee0lv_21
Snippet: Finally, 10 and 55 virus-specific FSFs (V) were detected in the proteomes of bacterioviruses and eukaryoviruses, respectively (none in archaeoviruses, Figure 2, Table 2 ). These protein domains represent crucial viral functions involved in viral pathogenicity and virion synthesis and could therefore become hot targets for designing novel therapeutics against contemporary viruses. Their origin however cannot be attributed to cell-to-virus HGT, as .....
Document: Finally, 10 and 55 virus-specific FSFs (V) were detected in the proteomes of bacterioviruses and eukaryoviruses, respectively (none in archaeoviruses, Figure 2, Table 2 ). These protein domains represent crucial viral functions involved in viral pathogenicity and virion synthesis and could therefore become hot targets for designing novel therapeutics against contemporary viruses. Their origin however cannot be attributed to cell-to-virus HGT, as these FSFs are completely absent in cellular proteomes. They could originate either directly in viral lineages during replication inside host cells (refer to the "virocell" concept, Forterre, 2011) or represent ancient proteins relics of an early origin of viruses. Testing either of these two scenarios via data-driven approaches remains an open challenge though insights are starting to emerge (Nasir and Caetano-Anollés, 2015) .
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