Author: Kang, Hee; Park, Sung-Hyun; Yun, Jeong-Moon; Nam, Tae-Gyu; Kim, Young-Eun; Kim, Dae-Ok; Kim, Youn Jung
Title: Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity Document date: 2014_3_7
ID: 0bqhbm9p_35
Snippet: PMA stimulates THP-1 cells to enter cell arrest via a Raf-MEK-ERK1/2 signaling pathway, after which they become differentiated [16, 23] . We tried to identify the role of ERK1/2 in PMA-induced SRA synthesis. Treatment with U0126, an inhibitor of ERK1/2 activation, strongly inhibited SRA protein in PMA-stimulated THP-1 cells ( Figure 5A ). We found that U0126 completely inhibited the attachment of cells into the culture plate and thus blocked the .....
Document: PMA stimulates THP-1 cells to enter cell arrest via a Raf-MEK-ERK1/2 signaling pathway, after which they become differentiated [16, 23] . We tried to identify the role of ERK1/2 in PMA-induced SRA synthesis. Treatment with U0126, an inhibitor of ERK1/2 activation, strongly inhibited SRA protein in PMA-stimulated THP-1 cells ( Figure 5A ). We found that U0126 completely inhibited the attachment of cells into the culture plate and thus blocked the uptake of acetyl LDL (data not shown). SRA protein synthesis in PMA-differentiated THP-1 cells was suppressed at 100 μg/ml of CWE ( Figure 5B ). CWE also inhibited PMA-stimulated ERK1/2 activation but in a concentration-independent manner ( Figure 5D ).
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