Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection Document date: 2020_1_20
ID: 0zr2e8lh_36
Snippet: In summary, ZIKV localizes to the ER for viral genome replication. These additional transcriptional and translational processes impart significant burden on the ER leading to ER stress and UPR induction. During the early stage of UPR, UPR effectors elicit adaptive responses to mitigate ER stress. These responses include the upregulation of chaperones and protein processing enzymes to promote and rectify protein folding, induction of ERAD to degra.....
Document: In summary, ZIKV localizes to the ER for viral genome replication. These additional transcriptional and translational processes impart significant burden on the ER leading to ER stress and UPR induction. During the early stage of UPR, UPR effectors elicit adaptive responses to mitigate ER stress. These responses include the upregulation of chaperones and protein processing enzymes to promote and rectify protein folding, induction of ERAD to degrade misfolded/unfolded proteins, global translational arrest, and activation of autophagy and/or reticulophagy.
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