Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection Document date: 2020_1_20
ID: 0zr2e8lh_45
Snippet: In ZIKV-infected cells, depletion of FAM134B protein renders notable ER expansion and significant upregulation of ZIKV replication activity [80] . This is due to the proteolytic activity of ZIKV NS2B-NS3 that cleaves exposed RHD located on FAM134B protein, which impedes the oligomerization of FAM134B proteins and consequently, prevents ER membrane excision and reticulophagy from taking place [80] . This efficiently blocks host cell innate defense.....
Document: In ZIKV-infected cells, depletion of FAM134B protein renders notable ER expansion and significant upregulation of ZIKV replication activity [80] . This is due to the proteolytic activity of ZIKV NS2B-NS3 that cleaves exposed RHD located on FAM134B protein, which impedes the oligomerization of FAM134B proteins and consequently, prevents ER membrane excision and reticulophagy from taking place [80] . This efficiently blocks host cell innate defense mechanism from degrading ZIKV proteins.
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