Selected article for: "genome sense and open reading frame"
Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection
  • Document date: 2020_1_20
    • ID: 0zr2e8lh_5
    Snippet: The ZIKV genome is a positive-sense, single-stranded RNA ((+)ssRNA) of approximately 11,000 bases in length [2] . ZIKV genome contains a single open reading frame that encodes three structural and seven non-structural (NS) proteins. These structural proteins consist of capsid (C), pre-membrane (prM), and envelope (Env) proteins, which are predominantly involved in viral pathogenesis and virion structure. The seven non-structural proteins, NS1, NS.....
    Document: The ZIKV genome is a positive-sense, single-stranded RNA ((+)ssRNA) of approximately 11,000 bases in length [2] . ZIKV genome contains a single open reading frame that encodes three structural and seven non-structural (NS) proteins. These structural proteins consist of capsid (C), pre-membrane (prM), and envelope (Env) proteins, which are predominantly involved in viral pathogenesis and virion structure. The seven non-structural proteins, NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 proteins, largely contribute towards the purposes of viral pathogenesis, replication, and immune evasion [17] . ZIKV utilizes host translational machinery to produce a single polyprotein that is further cleaved by viral NS2B-NS3 serine protease and host cell protease into functional viral proteins [18] . These viral proteins are then distributed to cellular compartments for various functions [19] .

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