Author: M. Gordon Joyce; Rajeshwer S. Sankhala; Wei-Hung Chen; Misook Choe; Hongjun Bai; Agnes Hajduczki; Lianying Yan; Spencer L. Sterling; Caroline E. Peterson; Ethan C. Green; Clayton Smith; Natalia de Val; Mihret Amare; Paul Scott; Eric D. Laing; Christopher C. Broder; Morgane Rolland; Nelson L. Michael; Kayvon Modjarrad
Title: A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein Document date: 2020_3_17
ID: ebbzx8yr_15
Snippet: In summary, our data represents the most detailed structural information for the SARS-CoV-2 RBD to date and the first structure of the SARS-CoV-2 in complex with a human antibody. The presence of "cryptic" but protective epitopes for influenza (Bangaru et al., 2019) , and Ebola viruses (West et al., 2018) , have been previously described. The identification of a novel "cryptic" epitope for betacoronaviruses including SARS-CoV, and SARS-CoV-2 high.....
Document: In summary, our data represents the most detailed structural information for the SARS-CoV-2 RBD to date and the first structure of the SARS-CoV-2 in complex with a human antibody. The presence of "cryptic" but protective epitopes for influenza (Bangaru et al., 2019) , and Ebola viruses (West et al., 2018) , have been previously described. The identification of a novel "cryptic" epitope for betacoronaviruses including SARS-CoV, and SARS-CoV-2 highlight a novel viral vulnerability that can be harnessed in combination with ACE2 receptor site targeting monoclonal antibodies for vaccine and therapeutic countermeasure development.
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