Author: De Jong, Cornelis N.; Saes, Lotte; Klerk, Clara P. W.; Van der Klift, Marjolein; Cornelissen, Jan J.; Broers, Annoek E. C.
Title: Etanercept for steroid-refractory acute graft-versus-host disease: A single center experience Document date: 2017_10_26
ID: 1hcp36cw_30
Snippet: The difference in ORR and survival rate as observed in these studies as compared to the present study might be explained by the type and grade of GVHD involved. Our study included a relatively high proportion of patients with severe stage III and IV aGVHD with bowel involvement, which is a well-known adverse prognostic factor for response to therapy [4] . In addition, the combination of different agents with etanercept in some studies and variabl.....
Document: The difference in ORR and survival rate as observed in these studies as compared to the present study might be explained by the type and grade of GVHD involved. Our study included a relatively high proportion of patients with severe stage III and IV aGVHD with bowel involvement, which is a well-known adverse prognostic factor for response to therapy [4] . In addition, the combination of different agents with etanercept in some studies and variable definitions of SR-aGVHD limit direct comparison of results. Moreover, interpretation of clinical response may be difficult, especially in case of GVHD of the gut.
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