Author: Borkosky, Silvia S.; Whitley, Corinna; Kopp-Schneider, Annette; zur Hausen, Harald; deVilliers, Ethel-Michele
Title: Epstein-Barr Virus Stimulates Torque Teno Virus Replication: A Possible Relationship to Multiple Sclerosis Document date: 2012_2_22
ID: 0fl0heq1_3
Snippet: Infection-induced molecular mimicry has been implicated in several autoimmune diseases including MS [41] [42] [43] [44] . CD4 + T lymphocytes responding to the latent EBV nuclear antigen-1 (EBNA-1) are increased in patients with MS [45, 46] and these cross react with myelin antigens [47] . Our previous study [43] demonstrated the response of clonally expanded CD4 + T cells isolated from an MS patient to the poly-arginine motif present in the open.....
Document: Infection-induced molecular mimicry has been implicated in several autoimmune diseases including MS [41] [42] [43] [44] . CD4 + T lymphocytes responding to the latent EBV nuclear antigen-1 (EBNA-1) are increased in patients with MS [45, 46] and these cross react with myelin antigens [47] . Our previous study [43] demonstrated the response of clonally expanded CD4 + T cells isolated from an MS patient to the poly-arginine motif present in the open reading frame 1 (ORF1) of certain torque teno virus (TTV) types. Serum samples from this patient, taken during exacerbation and 24 months later, harboured TTV DNA sequences. In addition, we demonstrated TTV DNA in 6 of 13 brain samples, 12 from MS brain and one in HHV-6 encephalitis brain.
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