Selected article for: "frozen plasma and passive transfer"

Author: Proverbio, D.; Spada, E.; Baggiani, L.; Bagnagatti De Giorgi, G.; Roggero, N.; Belloli, A.; Pravettoni, D.; Perego, R.
Title: Effects of Storage Time on Total Protein and Globulin Concentrations in Bovine Fresh Frozen Plasma Obtained for Transfusion
  • Document date: 2015_2_12
  • ID: 0c5c2sze_24
    Snippet: The comparison of analysis of bovine plasma with human ranges of biological variation may be erroneous, and without species-specific ranges of biological variability, definitive conclusions cannot be drawn. In this study the maximal percentage of variation observed between fresh and frozen plasma was not considered clinically relevant and would not be expected to lead to misinterpretation of the results [17] . Thus, this study demonstrates that i.....
    Document: The comparison of analysis of bovine plasma with human ranges of biological variation may be erroneous, and without species-specific ranges of biological variability, definitive conclusions cannot be drawn. In this study the maximal percentage of variation observed between fresh and frozen plasma was not considered clinically relevant and would not be expected to lead to misinterpretation of the results [17] . Thus, this study demonstrates that in bovine plasma stored at −20 ∘ C changes in protein fractions occur in TP, ALB, and beta-2 globulin expressed as g/dL after 1 month and 6 and 12 months. Since one of the main reasons for use of bovine frozen plasma is the passive transfer of immunity for treatment of hypogammaglobulinemia in calves, the preservation of the gamma globulin fraction is essential. In our study there was no difference between the gamma globulin fraction expressed as g/dL and the percentage in fresh and thawed plasma at any time of storage studied. So bovine fresh frozen plasma seems to be suitable for treatment of hypogammaglobulinemia (failure of passive transfer of immunity) in calves when stored for 12 months at −20 ∘ C.

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