Selected article for: "ANOVA variance analysis and treatment period"
Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study
  • Document date: 2019_12_19
    • ID: 15e043uf_25
    Snippet: The primary outcome was evaluated using an analysis of variance (ANOVA) on the outcome variable with treatment as factor and pre-treatment (Visit 1) LAR as a covariate. The results were presented as a ratio of means. The secondary outcome variable, AUC-based EAR, was analysed in the same way as AUC-based LAR. All other secondary outcome variables such as biomarkers in sputum, and methacholine PC 20 were measured both prior to allergen challenge a.....
    Document: The primary outcome was evaluated using an analysis of variance (ANOVA) on the outcome variable with treatment as factor and pre-treatment (Visit 1) LAR as a covariate. The results were presented as a ratio of means. The secondary outcome variable, AUC-based EAR, was analysed in the same way as AUC-based LAR. All other secondary outcome variables such as biomarkers in sputum, and methacholine PC 20 were measured both prior to allergen challenge and post challenge, at visits before treatment, and 1 and 4 weeks after treatment period. (Additional file 1: Figure S2 ). All of these secondary measurements were analysed using ANOVA. Methacholine PC 20 data were estimated by loglinear interpolation: PC 20

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