Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study Document date: 2019_12_19
ID: 15e043uf_55
Snippet: We conclude that intranasal AZD8848 attenuated allergen-induced LAR and prevented allergen-induced increases in AHR in patients with allergic asthma at 1 week post-treatment. When administered onceweekly for 8 weeks, AZD8848 was generally well tolerated. This study demonstrates that intranasal administration of a TLR7 agonist, such as AZD8848, can ameliorate an allergen-induced response in the lower airways, carried out one week following the ces.....
Document: We conclude that intranasal AZD8848 attenuated allergen-induced LAR and prevented allergen-induced increases in AHR in patients with allergic asthma at 1 week post-treatment. When administered onceweekly for 8 weeks, AZD8848 was generally well tolerated. This study demonstrates that intranasal administration of a TLR7 agonist, such as AZD8848, can ameliorate an allergen-induced response in the lower airways, carried out one week following the cessation of dosing.
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