Author: Meng, Fandan; Wu, Nai-Huei; Seitz, Maren; Herrler, Georg; Valentin-Weigand, Peter
Title: Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions Document date: 2016_5_27
ID: 0jsc81sy_25
Snippet: The damage of the epithelial cells promotes streptococcal infection in different ways. It results in the loss of their barrier function and allows the bacteria to get access to deeper areas of the epithelium that are usually not exposed to the environment. This conclusion is supported by our infection studies with PCLS, another culture system for differentiated airway epithelial cells 37 . It has been suggested that dead cells may provide a rich .....
Document: The damage of the epithelial cells promotes streptococcal infection in different ways. It results in the loss of their barrier function and allows the bacteria to get access to deeper areas of the epithelium that are usually not exposed to the environment. This conclusion is supported by our infection studies with PCLS, another culture system for differentiated airway epithelial cells 37 . It has been suggested that dead cells may provide a rich source of nutrition and growth factors and thus enhance streptococcal growth 48 . We found larger numbers of bacteria in areas where the epithelium had been damaged. Interestingly, the infection with the complemented strain cW461F, which could only express subcytolytic toxin effects, revealed a high number of invasive bacteria in PBEC but only moderate damaging effects. These results demonstrate that macropore-formation acticity and subcytolytic effects of suilysin promote invasion of S. suis.
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