Selected article for: "placebo group and statistical significance"
Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study
  • Document date: 2019_12_19
    • ID: 15e043uf_31
    Snippet: At baseline, post-allergen average LAR fall in FEV 1 (SD) was 0.81 L (0.45) in the AZD8848 group and 1.01 L (0.78) in the placebo group. At 1 week after the last dose of treatment, AZD8848 significantly reduced average LAR fall in FEV 1 by 27% compared with placebo (p = 0.035; Fig. 2 ). This effect was not sustained at 4 weeks after the last dose of AZD8848 (p = 0.349; Fig. 2 ). AZD8848 showed a trend towards decreased maximal LAR fall in FEV 1 v.....
    Document: At baseline, post-allergen average LAR fall in FEV 1 (SD) was 0.81 L (0.45) in the AZD8848 group and 1.01 L (0.78) in the placebo group. At 1 week after the last dose of treatment, AZD8848 significantly reduced average LAR fall in FEV 1 by 27% compared with placebo (p = 0.035; Fig. 2 ). This effect was not sustained at 4 weeks after the last dose of AZD8848 (p = 0.349; Fig. 2 ). AZD8848 showed a trend towards decreased maximal LAR fall in FEV 1 versus placebo at 1 week after dosing, but this reduction did not reach statistical significance (18% decrease vs placebo; p = 0.076).

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