Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study Document date: 2019_12_19
ID: 15e043uf_48
Snippet: AZD8848 is the first intra-nasally administered immunomodulatory compound shown to attenuate allergeninduced LAR and AHR at 1 week after treatment. These effects were not observed at 4 weeks after the final dose. Further studies are needed to evaluate the potential duration of effect of AZD8848 at different dosing frequencies and durations and to explore if it may be possible to reset the immune system to reduce or minimise the allergic response .....
Document: AZD8848 is the first intra-nasally administered immunomodulatory compound shown to attenuate allergeninduced LAR and AHR at 1 week after treatment. These effects were not observed at 4 weeks after the final dose. Further studies are needed to evaluate the potential duration of effect of AZD8848 at different dosing frequencies and durations and to explore if it may be possible to reset the immune system to reduce or minimise the allergic response with this treatment approach.
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