Evaluation of the efficacy of a trivalent vaccine mixture against a triple challenge with Mycoplasma hyopneumoniae, PCV2, and PRRSV and the efficacy comparison of the respective monovalent vaccines against a single challenge

Oh, Taehwan; Park, Kee Hwan; Yang, Siyeon; Jeong, Jiwoon; Kang, Ikjae; Park, Changhoon; Chae, Chanhee

The Vac3FLEX/Ch3 and VacPRRS/ChPRRSV groups had a significantly higher (P < 0.05) numbers of PRRSVspecific IFN-γ-SC in their PBMC compared to the UnVac/ Ch3 and UnVac/ChPRRSV groups from − 14 to 14 dpc. The Vac3FLEX/Ch3, VacPRRS/ChPRRSV, and UnVac/ ChPRRSV groups had a significantly higher (P < 0.05) number of PRRSV-specific IFN-γ-SC in their PBMC compared to the UnVac/Ch3 group at 28 dpc (Fig. 4c) . The mean numbers of M. hyopneumoniae-, PCV2-and PRRSVspecific IFN-γ-SC in the UnVac/UnCh group remained at basal levels (< 20 cells/10 6 PBMC) throughout the study.