Evaluation of the efficacy of a trivalent vaccine mixture against a triple challenge with Mycoplasma hyopneumoniae, PCV2, and PRRSV and the efficacy comparison of the respective monovalent vaccines against a single challenge

Oh, Taehwan; Park, Kee Hwan; Yang, Siyeon; Jeong, Jiwoon; Kang, Ikjae; Park, Changhoon; Chae, Chanhee

In this study, we have presented evidence that a trivalent vaccine mixture is efficacious against challenge with three pathogens (M. hyopneumoniae, PCV2, and PRRSV) and it is similar to the efficacies of each individual monovalent vaccine against their respective single challenge. Additional interference studies would need to be conducted to establish this ratio and to determine compatibility of the trivalent vaccine mixture compared to the respective monovalent vaccines, especially in regard to the effect on the viability of PRRSV MLV vaccine. In addition, it is difficult to draw a full conclusion from the direct comparison with the respective monovalent vaccines, because of the different challenge inocula between the trivalent vaccine mixture group and the monovalent vaccine groups. Additional test groups of pigs vaccinated with monovalent vaccine followed by a triple challenge or vaccinated with the trivalent vaccine mixture followed by a single challenge with either M. hyopneumoniae, PCV2 or PRRSV should be included for further evaluation.