Selected article for: "antibody titer and microneutralization assay"

Author: Khattar, Sunil K.; Nayak, Baibaswata; Kim, Shin-Hee; Xiao, Sa; Samal, Sweety; Paldurai, Anandan; Buchholz, Ursula J.; Collins, Peter L.; Samal, Siba K.
Title: Evaluation of the Replication, Pathogenicity, and Immunogenicity of Avian Paramyxovirus (APMV) Serotypes 2, 3, 4, 5, 7, and 9 in Rhesus Macaques
  • Document date: 2013_10_10
  • ID: 0littefv_30
    Snippet: The ability of the serum samples collected on day 28 to neutralize the respective APMV serotype was assessed by a microneutralization assay ( Table 4 ). The antisera from the monkeys immunized with wt APMV-9 had the highest mean neutralizing antibody titer of log 2 9.560.6. The next highest titer was observed in monkeys infected with wt rAPMV-3 (6.361.0). The neutralizing antibody titer in monkeys infected with other serotypes decreased in the or.....
    Document: The ability of the serum samples collected on day 28 to neutralize the respective APMV serotype was assessed by a microneutralization assay ( Table 4 ). The antisera from the monkeys immunized with wt APMV-9 had the highest mean neutralizing antibody titer of log 2 9.560.6. The next highest titer was observed in monkeys infected with wt rAPMV-3 (6.361.0). The neutralizing antibody titer in monkeys infected with other serotypes decreased in the order: wt rAPMV-4 (6.060.8) . rAPMV-4/Fc-BC (4.861.0) . wt APMV-7 (4.361.5) . wt APMV-2 (3.061.4) . rAPMV-7/Fcs-5B (2.861.0). Surprisingly, serum neutralizing antibodies were not detected in the case of rAPMV-2 (type 1 Africa). In this study, no direct correlation was found between HI titer and neutralizing titer.

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