Author: Khattar, Sunil K.; Nayak, Baibaswata; Kim, Shin-Hee; Xiao, Sa; Samal, Sweety; Paldurai, Anandan; Buchholz, Ursula J.; Collins, Peter L.; Samal, Siba K.
Title: Evaluation of the Replication, Pathogenicity, and Immunogenicity of Avian Paramyxovirus (APMV) Serotypes 2, 3, 4, 5, 7, and 9 in Rhesus Macaques Document date: 2013_10_10
ID: 0littefv_34
Snippet: Therefore, the goal of this study was to evaluate the replication and pathogenicity of a number of non-NDV APMV serotypes in non-human primates. Rhesus macaques were evaluated for permissiveness to infection, clinical disease, magnitude of replication, shedding and induction of antibodies. Rhesus macaques have been used commonly as a non-human primate model to study replication and pathogenicity of various viruses, to screen attenuation phenotype.....
Document: Therefore, the goal of this study was to evaluate the replication and pathogenicity of a number of non-NDV APMV serotypes in non-human primates. Rhesus macaques were evaluated for permissiveness to infection, clinical disease, magnitude of replication, shedding and induction of antibodies. Rhesus macaques have been used commonly as a non-human primate model to study replication and pathogenicity of various viruses, to screen attenuation phenotypes of live virus vaccines, and to evaluate immune responses of virus vaccine candidates. The safety, immunogenicity, and protective efficacy of NDV has also been demonstrated in this model [29] [30] [31] [32] [33] 51] .
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