Author: Borkosky, Silvia S.; Whitley, Corinna; Kopp-Schneider, Annette; zur Hausen, Harald; deVilliers, Ethel-Michele
Title: Epstein-Barr Virus Stimulates Torque Teno Virus Replication: A Possible Relationship to Multiple Sclerosis Document date: 2012_2_22
ID: 0fl0heq1_4
Snippet: The disease-inducing potential of TTV and mechanisms involved in their replication are not understood. TTV was first identified in a Japanese patient suffering post-transfusion hepatitis of unknown etiology [48] . A multitude of TTV genotypes with marked genetic heterogeneity has subsequently been identified [49] . Primary infection occurs very early in life with 47,6% of children infected with at least 3 TTV types at 6 months of age and 93% at 1.....
Document: The disease-inducing potential of TTV and mechanisms involved in their replication are not understood. TTV was first identified in a Japanese patient suffering post-transfusion hepatitis of unknown etiology [48] . A multitude of TTV genotypes with marked genetic heterogeneity has subsequently been identified [49] . Primary infection occurs very early in life with 47,6% of children infected with at least 3 TTV types at 6 months of age and 93% at 1 year of age [50, 51] . Their genomic diversity and ubiquitous prevalence have posed main obstacles in attempts to define a role for TT viruses in the pathogenesis of disease [49, 52, 53] . TTV DNA has been demonstrated in many organs and tissues [43, [54] [55] [56] . Peripheral blood act as reservoir for TT viruses [57, 58] and replicative viral DNA has been demonstrated in bone marrow cells and the liver [59, 60] . Other reports have implicated TTV infections in autoimmune diseases [52, [61] [62] [63] .
Search related documents:
Co phrase search for related documents- autoimmune disease and disease induce: 1, 2, 3, 4, 5, 6, 7, 8
- autoimmune disease and disease induce potential: 1
- autoimmune disease and disease pathogenesis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- autoimmune disease and marrow cell: 1
- bone marrow cell and disease pathogenesis: 1
- bone marrow cell and marrow cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- disease induce and post transfusion hepatitis: 1
- disease pathogenesis and early occur: 1, 2, 3, 4
- disease pathogenesis and genetic heterogeneity: 1, 2
- disease pathogenesis and genomic diversity: 1
- disease pathogenesis and marrow cell: 1, 2
- genetic heterogeneity and genomic diversity: 1, 2
- genetic heterogeneity and marked genetic heterogeneity: 1
Co phrase search for related documents, hyperlinks ordered by date