Author: Borkosky, Silvia S.; Whitley, Corinna; Kopp-Schneider, Annette; zur Hausen, Harald; deVilliers, Ethel-Michele
Title: Epstein-Barr Virus Stimulates Torque Teno Virus Replication: A Possible Relationship to Multiple Sclerosis Document date: 2012_2_22
ID: 0fl0heq1_4
Snippet: The disease-inducing potential of TTV and mechanisms involved in their replication are not understood. TTV was first identified in a Japanese patient suffering post-transfusion hepatitis of unknown etiology [48] . A multitude of TTV genotypes with marked genetic heterogeneity has subsequently been identified [49] . Primary infection occurs very early in life with 47,6% of children infected with at least 3 TTV types at 6 months of age and 93% at 1.....
Document: The disease-inducing potential of TTV and mechanisms involved in their replication are not understood. TTV was first identified in a Japanese patient suffering post-transfusion hepatitis of unknown etiology [48] . A multitude of TTV genotypes with marked genetic heterogeneity has subsequently been identified [49] . Primary infection occurs very early in life with 47,6% of children infected with at least 3 TTV types at 6 months of age and 93% at 1 year of age [50, 51] . Their genomic diversity and ubiquitous prevalence have posed main obstacles in attempts to define a role for TT viruses in the pathogenesis of disease [49, 52, 53] . TTV DNA has been demonstrated in many organs and tissues [43, [54] [55] [56] . Peripheral blood act as reservoir for TT viruses [57, 58] and replicative viral DNA has been demonstrated in bone marrow cells and the liver [59, 60] . Other reports have implicated TTV infections in autoimmune diseases [52, [61] [62] [63] .
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