Author: Meng, Fandan; Ren, Yudong; Suo, Siqingaowa; Sun, Xuejiao; Li, Xunliang; Li, Pengchong; Yang, Wei; Li, Guangxing; Li, Lu; Schwegmann-Wessels, Christel; Herrler, Georg; Ren, Xiaofeng
Title: Evaluation on the Efficacy and Immunogenicity of Recombinant DNA Plasmids Expressing Spike Genes from Porcine Transmissible Gastroenteritis Virus and Porcine Epidemic Diarrhea Virus Document date: 2013_3_19
ID: 081o2zmd_2
Snippet: PEDV is related to TGEV and bears similarities in its structure as well as in the clinical disease and lesions induced [1, 9] . PEDV was first separated in Belgium and the United Kingdom in 1978 [2, 28, 47] . The disease is characterized by severe diarrhea, vomiting, dehydration, and death, and has a mortality rate of up to 90% [35] . Since 1978, the disease has frequently broken out in many swine-raising countries and has resulted in severe econ.....
Document: PEDV is related to TGEV and bears similarities in its structure as well as in the clinical disease and lesions induced [1, 9] . PEDV was first separated in Belgium and the United Kingdom in 1978 [2, 28, 47] . The disease is characterized by severe diarrhea, vomiting, dehydration, and death, and has a mortality rate of up to 90% [35] . Since 1978, the disease has frequently broken out in many swine-raising countries and has resulted in severe economic losses in Asia, notably in China, Japan and Korea [6, 14, 18] . In 1996, PED outbreaks have been reported to be responsible for the death of more than 39,000 piglets in Japan [42] . PED caused not only the death of neonatal piglets, but also the weight loss in fattening pigs due to PEDV-induced diarrhea. Therefore, it is important to develop an effective vaccine preventing PEDV infection.
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