Author: Meng, Fandan; Ren, Yudong; Suo, Siqingaowa; Sun, Xuejiao; Li, Xunliang; Li, Pengchong; Yang, Wei; Li, Guangxing; Li, Lu; Schwegmann-Wessels, Christel; Herrler, Georg; Ren, Xiaofeng
Title: Evaluation on the Efficacy and Immunogenicity of Recombinant DNA Plasmids Expressing Spike Genes from Porcine Transmissible Gastroenteritis Virus and Porcine Epidemic Diarrhea Virus Document date: 2013_3_19
ID: 081o2zmd_44
Snippet: T cells are important effector cells of immune responses. Their activation causes the secretion of cytokines that advance cellular and humoral immune responses and mediate CTL activity. As such, monitoring CTL activity provides a good readout for immune stimulation. In this study, spleen and blood-derived lymphocytes from immunized mice clearly showed that immunization with pIRES-(TGEV-S1-PEDV-S1) and pIRES-(TGEV-S1-PEDV-S) significantly induced .....
Document: T cells are important effector cells of immune responses. Their activation causes the secretion of cytokines that advance cellular and humoral immune responses and mediate CTL activity. As such, monitoring CTL activity provides a good readout for immune stimulation. In this study, spleen and blood-derived lymphocytes from immunized mice clearly showed that immunization with pIRES-(TGEV-S1-PEDV-S1) and pIRES-(TGEV-S1-PEDV-S) significantly induced T cell proliferation. When stimulated with purified recombinant PEDV-S1 protein, there was Figure 8 . Levels of neutralizing antibodies in mice treated with pIRES-(TGEV-S1-PEDV-S1) and pIRES-(TGEV-S1-PEDV-S). Anti-PEDV and anti-TGEV neutralizing antibodies in immunized mice were detected by plaque reduction assay with different serum dilutions from blood samples taken at 28 days after the injection of the plasmid DNAs. doi:10.1371/journal.pone.0057468.g008 higher T lymphocyte proliferation in the pIRES-(TGEV-S1-PEDV-S) group than in the pIRES-(TGEV-S1-PEDV-S1) group.
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