Author: Khattar, Sunil K.; Nayak, Baibaswata; Kim, Shin-Hee; Xiao, Sa; Samal, Sweety; Paldurai, Anandan; Buchholz, Ursula J.; Collins, Peter L.; Samal, Siba K.
Title: Evaluation of the Replication, Pathogenicity, and Immunogenicity of Avian Paramyxovirus (APMV) Serotypes 2, 3, 4, 5, 7, and 9 in Rhesus Macaques Document date: 2013_10_10
ID: 0littefv_42
Snippet: In summary, we have evaluated the replication and pathogenicity of APMV serotypes-2, -3, -4, -5, -7, and -9 in non-human primates. These respiratory viruses are highly restricted for replication in respiratory tract of rhesus macaques. We have also demonstrated a substantial level of immunogenicity for wt APMV-2, -3 -7 and -9 and recombinant wt APMV-4, APMV-4/Fc-BC, and APMV-7/Fcs-5B in this non-human primate model. As these APMVs are serological.....
Document: In summary, we have evaluated the replication and pathogenicity of APMV serotypes-2, -3, -4, -5, -7, and -9 in non-human primates. These respiratory viruses are highly restricted for replication in respiratory tract of rhesus macaques. We have also demonstrated a substantial level of immunogenicity for wt APMV-2, -3 -7 and -9 and recombinant wt APMV-4, APMV-4/Fc-BC, and APMV-7/Fcs-5B in this non-human primate model. As these APMVs are serologically distinct from NDV and from each other, they may be developed as vectors and used in heterologous primeboost combinations to induce robust systemic and mucosal immune responses against foreign antigens.
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