Evaluation of the efficacy of a trivalent vaccine mixture against a triple challenge with Mycoplasma hyopneumoniae, PCV2, and PRRSV and the efficacy comparison of the respective monovalent vaccines against a single challenge

Oh, Taehwan; Park, Kee Hwan; Yang, Siyeon; Jeong, Jiwoon; Kang, Ikjae; Park, Changhoon; Chae, Chanhee

The Vac3FLEX/Ch3 and VacPRRS/ChPRRSV groups had a significantly higher (P < 0.05) PRRSV ELISA S/P ratio compared to the UnVac/Ch3 and UnVac/ ChPRRSV groups from − 14 to 28 dpc. The UnVac/ ChPRRSV group had a significantly higher (P < 0.05) Fig. 1 a Mean respiratory scores between trivalent vaccine mixture and respective monovalent M. hyopneumoniae vaccine. b Mean respiratory scores between trivalent vaccine mixture and respective monovalent PCV2 vaccine. c Mean respiratory scores between trivalent vaccine mixture and respective monovalent PRRS vaccine. Variation is expressed as the standard deviation. Different letters within a sampling point mean statistically significant differences (P < 0.05) PRRSV ELISA S/P ratio compared to the UnVac/Ch3 group at 7, 14, and 28 dpc (Fig. 3c) . No antibodies against M. hyopneumoniae, PCV2, and PRRSV were detected in any of the pigs from UnVac/UnCh group (Fig. 3c ). All pigs from all 9 groups were negative for influenza A virus antibodies.