Evaluation of the Replication, Pathogenicity, and Immunogenicity of Avian Paramyxovirus (APMV) Serotypes 2, 3, 4, 5, 7, and 9 in Rhesus Macaques

Khattar, Sunil K.; Nayak, Baibaswata; Kim, Shin-Hee; Xiao, Sa; Samal, Sweety; Paldurai, Anandan; Buchholz, Ursula J.; Collins, Peter L.; Samal, Siba K.

The serum HI antibody titers induced in rhesus monkeys by wt APMV-2, wt APMV-3, wt APMV-7, rAPMV-7/Fcs-5B, and wt APMV-9 was either higher or equal to the HI antibody titers induced by mesogenic NDV strain BC in African green monkeys in previous studies [52] . These serotypes are thus candidates for further development as vaccines for human use. In the cases of wt rAPMV-4, rAPMV-4/Fc-BC, and wt APMV-5 (where not all of the monkeys seroconverted) and rAPMV-2 (type 1 Africa), the HI antibody titers were lower than that induced by NDV in a previous study [52] , suggesting that these serotypes are less promising. One incongruity in the present study is the low titers of HI antibodies, and lack of detectable neutralizing antibodies, induced by rAPMV-2 (type 1 Africa) despite the relatively robust replication of this vector and compared to the greater immunogenicity of its wt APMV-2 parent despite the lower replication of the parent.