Author: Meng, Fandan; Ren, Yudong; Suo, Siqingaowa; Sun, Xuejiao; Li, Xunliang; Li, Pengchong; Yang, Wei; Li, Guangxing; Li, Lu; Schwegmann-Wessels, Christel; Herrler, Georg; Ren, Xiaofeng
Title: Evaluation on the Efficacy and Immunogenicity of Recombinant DNA Plasmids Expressing Spike Genes from Porcine Transmissible Gastroenteritis Virus and Porcine Epidemic Diarrhea Virus Document date: 2013_3_19
ID: 081o2zmd_48
Snippet: As mice are not susceptible to infection by TGEV or PEDV we cannot use this animal model to perform challenge experiments and evaluate the protection rate of the DNA constructs. However, we did observe good immune responses of these DNA plasmids in this species. On the basis of this study, our further studies will include usage of pigs to optimize immunization procedures as well as to evaluate host immunity and protection induced by these DNA pla.....
Document: As mice are not susceptible to infection by TGEV or PEDV we cannot use this animal model to perform challenge experiments and evaluate the protection rate of the DNA constructs. However, we did observe good immune responses of these DNA plasmids in this species. On the basis of this study, our further studies will include usage of pigs to optimize immunization procedures as well as to evaluate host immunity and protection induced by these DNA plasmids to develop effective DNA vaccines for controlling TGE and PED.
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