Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy Document date: 2020_2_27
ID: egntml7e_73
Snippet: Lastly, in LPS tolerance cells, LC3B-II and ATG5 level markedly increased when knocking down VDR compared with negative control, and addition of AS making no difference (Figure 5h ). AS-promoting LC3B-II and ATG5 level in LPS tolerance cells was abrogated by overexpressing VDR (Figure 5i ). All the aforementioned findings indicated that AS's effect is autophagy-dependent through VDR in vitro......
Document: Lastly, in LPS tolerance cells, LC3B-II and ATG5 level markedly increased when knocking down VDR compared with negative control, and addition of AS making no difference (Figure 5h ). AS-promoting LC3B-II and ATG5 level in LPS tolerance cells was abrogated by overexpressing VDR (Figure 5i ). All the aforementioned findings indicated that AS's effect is autophagy-dependent through VDR in vitro.
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