Author: Borkosky, Silvia S.; Whitley, Corinna; Kopp-Schneider, Annette; zur Hausen, Harald; deVilliers, Ethel-Michele
Title: Epstein-Barr Virus Stimulates Torque Teno Virus Replication: A Possible Relationship to Multiple Sclerosis Document date: 2012_2_22
ID: 0fl0heq1_6
Snippet: Studies in the past concentrated on single virus infections as etiological factors of MS, whereas interactions between viruses in its pathogenesis have not been approached. Herpesviruses have been known to induce amplification of other viral genomes, as well as cellular sequences [68] [69] [70] [71] [72] . EBNA-1 enhances replication of Hepatitis C virus (HCV) [73] . The current study analysed the question whether EBV can stimulate or induce TTV .....
Document: Studies in the past concentrated on single virus infections as etiological factors of MS, whereas interactions between viruses in its pathogenesis have not been approached. Herpesviruses have been known to induce amplification of other viral genomes, as well as cellular sequences [68] [69] [70] [71] [72] . EBNA-1 enhances replication of Hepatitis C virus (HCV) [73] . The current study analysed the question whether EBV can stimulate or induce TTV replication in vitro. We have isolated a series of full-length TTV genomes from diseased brain of MS patients [67] . We transfected two of these TTV isolates into EBV-carrying cell lines. Two EBV-negative cell lines were used as controls. Quantitative PCR analyses clearly demonstrate a helper effect of EBV on the replication of the TTV genome. These results provide additional information for linking viral infections to the pathogenesis of MS.
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