Author: Camacho, Anton; Ballesteros, Sébastien; Graham, Andrea L.; Carrat, Fabrice; Ratmann, Oliver; Cazelles, Bernard
Title: Explaining rapid reinfections in multiple-wave influenza outbreaks: Tristan da Cunha 1971 epidemic as a case study Document date: 2011_12_22
ID: 12y420k8_33
Snippet: In agreement with the AoN hypothesis, it has been reported that a protective serum antibody response cannot be detected in approximately 20 per cent of subjects after natural influenza infection [38] . However, our estimate is much higher and indicates that about 50 per cent of the islanders did not mount a protective response following the first infection. It has been proposed that this lack of protective immunity could be related to a low prior.....
Document: In agreement with the AoN hypothesis, it has been reported that a protective serum antibody response cannot be detected in approximately 20 per cent of subjects after natural influenza infection [38] . However, our estimate is much higher and indicates that about 50 per cent of the islanders did not mount a protective response following the first infection. It has been proposed that this lack of protective immunity could be related to a low prior exposure to influenza [11] . Interestingly, the high level of consanguinity among the islanders, together with evidence that genetic bottlenecks occurred in the history of the population [39] , may also have led to the overrepresentation of an unusual genotype involved in the control of influenza.
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