Author: Camacho, Anton; Ballesteros, Sébastien; Graham, Andrea L.; Carrat, Fabrice; Ratmann, Oliver; Cazelles, Bernard
Title: Explaining rapid reinfections in multiple-wave influenza outbreaks: Tristan da Cunha 1971 epidemic as a case study Document date: 2011_12_22
ID: 12y420k8_34
Snippet: Furthermore, ecological factors including the dose of virus that initiates infection and the time interval between primary and secondary exposure may shape Win or AoN immunity, or indeed may make Win immunity appear as an AoN phenomenon. For example, the amount of virus in the lung determines the multiplicity of infection of innate antigen-presenting cells, which in turn affects their ability to induce subsequent adaptive responses [33] . Additio.....
Document: Furthermore, ecological factors including the dose of virus that initiates infection and the time interval between primary and secondary exposure may shape Win or AoN immunity, or indeed may make Win immunity appear as an AoN phenomenon. For example, the amount of virus in the lung determines the multiplicity of infection of innate antigen-presenting cells, which in turn affects their ability to induce subsequent adaptive responses [33] . Additionally, the rate at which immunity to reinfection develops is likely to interact with exposure rates to determine susceptibility. For example, when force of infection is high (as on TdC), many hosts are likely to Explaining rapid influenza reinfections A. Camacho et al. 3641 be re-exposed to virus before their window of susceptibility to reinfection closes. If force of infection is low, then most hosts will have closed that window before re-exposure (electronic supplementary material, text S7).
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