Author: Peters, Rebecca Marie; Schnee, Sarah Valerie; Tabatabai, Julia; Schnitzler, Paul; Pfeil, Johannes
Title: Evaluation of Alere i RSV for Rapid Detection of Respiratory Syncytial Virus in Children Hospitalized with Acute Respiratory Tract Infection Document date: 2017_3_24
ID: 1v56m2vq_18
Snippet: Alere i RSV log files were analyzed to report amplification time of all RSV-positive samples and to examine samples with invalid test results. Samples with invalid test results due to any kind of Alere i RSV test handling failure were excluded from the analysis. In contrast, samples with an invalid test result due to sample interference were considered false negative if the RT-PCR result was positive and as false positive if the RT-PCR reference .....
Document: Alere i RSV log files were analyzed to report amplification time of all RSV-positive samples and to examine samples with invalid test results. Samples with invalid test results due to any kind of Alere i RSV test handling failure were excluded from the analysis. In contrast, samples with an invalid test result due to sample interference were considered false negative if the RT-PCR result was positive and as false positive if the RT-PCR reference was negative. Possible reasons for invalid test results include inhibition of the amplification reaction or delayed amplification in samples with low viral load. Notably, the manufacturer recommends retesting of samples with invalid Alere i RSV results. However, as the volume of the respiratory samples used in our study was limited to 400 l, we were unable to follow this recommendation.
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