Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_2
Snippet: In mice, the type I IFN response is essential for protection against TBEV, JEV, WNV, and ZIKV infections [11] [12] [13] [14] [15] . The CNS has been considered as an immune-privileged tissue; however, recent studies have implicated the importance of intrinsic, innate antiviral responses within the CNS [16] [17] [18] [19] . In Langat virus (LGTV, Langat virus, low-virulent member of TBEV serogroup) infection, the local type I IFN response in the C.....
Document: In mice, the type I IFN response is essential for protection against TBEV, JEV, WNV, and ZIKV infections [11] [12] [13] [14] [15] . The CNS has been considered as an immune-privileged tissue; however, recent studies have implicated the importance of intrinsic, innate antiviral responses within the CNS [16] [17] [18] [19] . In Langat virus (LGTV, Langat virus, low-virulent member of TBEV serogroup) infection, the local type I IFN response in the CNS has been shown to be critical for the protection of mice against lethal encephalitis [11] . However, the CNS cell type responsible for producing IFN during TBEV infection has not been defined.
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