Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_49
Snippet: Here, we show that astrocytes are in an antiviral state and respond quickly to flavivirus infection by upregulating type 1 IFNs which limits neurotropic flavivirus spread. Secreted IFNs control viral replication by upregulating several innate immune pathways and induce cell survival. Our data suggest that although neurons seem to represent the main target for neurotropic flavivirus infection in vivo [64] , astrocytes are likely to play an importa.....
Document: Here, we show that astrocytes are in an antiviral state and respond quickly to flavivirus infection by upregulating type 1 IFNs which limits neurotropic flavivirus spread. Secreted IFNs control viral replication by upregulating several innate immune pathways and induce cell survival. Our data suggest that although neurons seem to represent the main target for neurotropic flavivirus infection in vivo [64] , astrocytes are likely to play an important role in responding to infection, amplifying the type I IFN response and limiting viral spread in both astrocytes and neurons.
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