Author: Frenzel, André; Hust, Michael; Schirrmann, Thomas
Title: Expression of Recombinant Antibodies Document date: 2013_7_29
ID: 06o7pa3d_42
Snippet: Recombination enzymes, like bacteriophage P1 Cre recombinase, lambda phage integrase, or yeast Flp recombinase can efficiently catalyze the site specific integration into defined chromosomal recombination exchange cassettes which have been introduced into producer cell lines (169, 170) . The 2A/furin technology allows expression of both IgG chains as a single gene due to post-translational auto-cleavage of the viral protease 2A encoded by the lin.....
Document: Recombination enzymes, like bacteriophage P1 Cre recombinase, lambda phage integrase, or yeast Flp recombinase can efficiently catalyze the site specific integration into defined chromosomal recombination exchange cassettes which have been introduced into producer cell lines (169, 170) . The 2A/furin technology allows expression of both IgG chains as a single gene due to post-translational auto-cleavage of the viral protease 2A encoded by the linker and subsequent processing by the Golgi protease furin (171, 172) .
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