Selected article for: "antibody fragment and fab fragment"
Author: Frenzel, André; Hust, Michael; Schirrmann, Thomas
Title: Expression of Recombinant Antibodies
  • Document date: 2013_7_29
    • ID: 06o7pa3d_20
    Snippet: Limited data concerning full-sized IgG expression in yeast is available. In an early study, a mouse-human chimeric antibody and its Fab fragment were produced in S. cerevisiae with a yield of 50-80 µg/L IgG and 200 µg/L Fab, respectively. The chimeric IgG mediated tumor specific binding and ADCC (antibody dependent cellular cytotoxicity) but no CDC (complement dependent cytotoxicity) (104). Using P. pastoris up to 1.4 g/L of a human IgG1 could .....
    Document: Limited data concerning full-sized IgG expression in yeast is available. In an early study, a mouse-human chimeric antibody and its Fab fragment were produced in S. cerevisiae with a yield of 50-80 µg/L IgG and 200 µg/L Fab, respectively. The chimeric IgG mediated tumor specific binding and ADCC (antibody dependent cellular cytotoxicity) but no CDC (complement dependent cytotoxicity) (104). Using P. pastoris up to 1.4 g/L of a human IgG1 could be expressed in a 40-L bioreactor (105).

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