Author: Frenzel, André; Hust, Michael; Schirrmann, Thomas
Title: Expression of Recombinant Antibodies Document date: 2013_7_29
ID: 06o7pa3d_27
Snippet: Recently, the eukaryotic parasite Leishmania tarentolae has been explored as an expression system for different recombinant proteins (125, 126). One major advantage of this expression system is the mammalian-like glycosylation pattern: this protozoa is able to perform O-glycosylation as well as N-glycosylation, which is highly conserved in mammalians (127). Consequently, L. tarentolae has been begun to be used for the production of recombinant an.....
Document: Recently, the eukaryotic parasite Leishmania tarentolae has been explored as an expression system for different recombinant proteins (125, 126). One major advantage of this expression system is the mammalian-like glycosylation pattern: this protozoa is able to perform O-glycosylation as well as N-glycosylation, which is highly conserved in mammalians (127). Consequently, L. tarentolae has been begun to be used for the production of recombinant antibodies: analysis of different signal peptides lead to a protein yield of 2-6 mg/L purified scFv (128).
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