Selected article for: "high level and immunosuppressive effect"
Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy
  • Document date: 2020_2_27
    • ID: egntml7e_86
    Snippet: Although the anti-inflammation or immunosuppressive effect of V D3 is reported to be tightly related to the function of VDR (Alroy, Towers & Freedman, 1995; Joshi et al., 2011; Lemire, Adams, Kermani-Arab, Bakke, Sakai & Jordan, 1985) , few studies have directly addressed the role of VDR in sepsis-induced immunosuppression. Based on our results, we speculated that the excessive high level of VDR during the immunosuppression stage of sepsis might .....
    Document: Although the anti-inflammation or immunosuppressive effect of V D3 is reported to be tightly related to the function of VDR (Alroy, Towers & Freedman, 1995; Joshi et al., 2011; Lemire, Adams, Kermani-Arab, Bakke, Sakai & Jordan, 1985) , few studies have directly addressed the role of VDR in sepsis-induced immunosuppression. Based on our results, we speculated that the excessive high level of VDR during the immunosuppression stage of sepsis might be related to the decreased inflammatory response. While AS could increase the survival rate of sepsis animals via its inhibition on high expression of VDR.

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