Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy

Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou

As we know, VDR is the receptor to recognize and bind V D3 . Will V D3 control VDR to achieve anti-sepsis effect? Although clinical investigation have shown a close correlation between Vitamin D deficiency in serum and excess morbidity and mortality of sepsis, suggesting vitamin D deficiency is closely related to sepsis (Dickerson et al., 2016) , it . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.26.966143 doi: bioRxiv preprint remains conflicting that Vitamin D supplementation improves the outcome of patients with sepsis (Kearns, Alvarez, Seidel & Tangpricha, 2015; Putzu et al., 2017) . Considering the extensive biological effects of Vitamin D, as well as its role in maintenance of homeostasis in organisms, it is necessary and important to maintain the physiological concentration of Vitamin D. Noteworthy, excessive vitamin D supplementation may be harmful rather than beneficial based on our results that excessive Vitamin D might induce the high level of VDR expression, which might lead to decreased immune function.