Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy

Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou

Till now, the outcome of therapeutic regime only aiming at a single stage of sepsis is disappointing and even worse. It might due to that the treatment time window is important for the therapeutic regimen of sepsis, but difficult to grasp. Giving anti-inflammatory drugs in hypo-inflammatory stage or pro-inflammatory therapy in hyper-inflammatory stage lead to failures even increasing mortalities in clinic (Hotchkiss, Monneret & Payen, 2013a; Rudick, Cornell & Agrawal, 2017) . Therefore, we considered that an immunoregulator might be an ideal drug for sepsis without limitation of treatment time window. Our results demonstrated that AS might be an immunoregulator for both hyper-and hypo-inflammatory stage of sepsis based on previous and current results.