Selected article for: "helical structure and heptad repeat"
Author: Hunt, Catherine L.; Lennemann, Nicholas J.; Maury, Wendy
Title: Filovirus Entry: A Novelty in the Viral Fusion World
  • Document date: 2012_2_7
    • ID: 1j9zmuub_42
    Snippet: The N-terminal GP 2 heptad repeat region (HR1) is a highly ordered, alpha-helical structure that serves as a platform or base for GP 1 and contains residues that are necessary for interactions with other GP 2 HR1s to form the trimeric structure of the pre-fusion GP [3, 7] . In the pre-fusion form, HR1 does not interact with the carboxy terminal heptad repeat region (HR2). Within the intact, pre-fusion trimer, HR2 appears to be disordered and was .....
    Document: The N-terminal GP 2 heptad repeat region (HR1) is a highly ordered, alpha-helical structure that serves as a platform or base for GP 1 and contains residues that are necessary for interactions with other GP 2 HR1s to form the trimeric structure of the pre-fusion GP [3, 7] . In the pre-fusion form, HR1 does not interact with the carboxy terminal heptad repeat region (HR2). Within the intact, pre-fusion trimer, HR2 appears to be disordered and was not included in the crystallized structure [7] .

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