Author: Meng, Fandan; Ren, Yudong; Suo, Siqingaowa; Sun, Xuejiao; Li, Xunliang; Li, Pengchong; Yang, Wei; Li, Guangxing; Li, Lu; Schwegmann-Wessels, Christel; Herrler, Georg; Ren, Xiaofeng
Title: Evaluation on the Efficacy and Immunogenicity of Recombinant DNA Plasmids Expressing Spike Genes from Porcine Transmissible Gastroenteritis Virus and Porcine Epidemic Diarrhea Virus Document date: 2013_3_19
ID: 081o2zmd_47
Snippet: In summary, to the best of our knowledge, this is the first time that the immunological efficacies triggered by PEDV S protein and the TGEV S protein were compared using a mouse model. Both the recombinant plasmids pIRES-(TGEV-S1-PEDV-S1) and pIRES-(TGEV-S1-PEDV-S) could elicit in mice cellular immunity, T-cell response as well as humoral response generating CTLs, helper T cells, particularly of Th1 cells, as well as specific neutralizing antibod.....
Document: In summary, to the best of our knowledge, this is the first time that the immunological efficacies triggered by PEDV S protein and the TGEV S protein were compared using a mouse model. Both the recombinant plasmids pIRES-(TGEV-S1-PEDV-S1) and pIRES-(TGEV-S1-PEDV-S) could elicit in mice cellular immunity, T-cell response as well as humoral response generating CTLs, helper T cells, particularly of Th1 cells, as well as specific neutralizing antibodies against PEDV and TGEV, respectively. It has been reported that an antigenic domain in the S gene that could elicit a strong antibody response and induce neutralizing antibodies has excellent immunogenicity on the C-terminal portion of the S protein [5] . Our results confirmed that the fulllength PEDV S gene induces a better immune response than the N-terminal half alone.
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