Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_48
Snippet: Neurons are the main target of neurotropic flavivirus infection; however, it is not clear if and how astrocytes influence viral growth in neurons. Therefore, supernatants from infected astrocytes were collected at different time points post infection and inactivated. Primary neurons were treated with supernatants before TBEV infection. The number of infected neurons decreased already when pretreated with supernatants from astrocytes infected for .....
Document: Neurons are the main target of neurotropic flavivirus infection; however, it is not clear if and how astrocytes influence viral growth in neurons. Therefore, supernatants from infected astrocytes were collected at different time points post infection and inactivated. Primary neurons were treated with supernatants before TBEV infection. The number of infected neurons decreased already when pretreated with supernatants from astrocytes infected for 3 h (Fig. 8e) . These data indicate that astrocytes can mediate a very fast antiviral effect on neurons already 3 h post infection.
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