Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_51
Snippet: Previous work has indicated that a local type I IFN response is indispensable for the control of viral replication in the CNS after flavivirus infection [11] . TBEV preferentially replicates in neurons [11, 33] , but why astrocytes are less susceptible to TBEV infection remains unclear. In the current study, we showed that astrocytes are initially infected by TBEV but showed strong inhibition of viral spread. Astrocytes showed a higher basal leve.....
Document: Previous work has indicated that a local type I IFN response is indispensable for the control of viral replication in the CNS after flavivirus infection [11] . TBEV preferentially replicates in neurons [11, 33] , but why astrocytes are less susceptible to TBEV infection remains unclear. In the current study, we showed that astrocytes are initially infected by TBEV but showed strong inhibition of viral spread. Astrocytes showed a higher basal level of ISG expression which enables the cells to rapidly respond with type I IFN production. Thus, astrocytes induce an early and strong antiviral response that limits viral spread in neurons and thereby plays a specific role in the innate antiviral defense in the CNS.
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