Author: Hunt, Catherine L.; Lennemann, Nicholas J.; Maury, Wendy
Title: Filovirus Entry: A Novelty in the Viral Fusion World Document date: 2012_2_7
ID: 1j9zmuub_32
Snippet: These observations were confirmed in Vero cells in a recent study by Wong et al. [80] . This group also extended the finding by selecting an infectious, recombinant VSV encoding EBOV GP over several passages to become resistant to the Cathepsin B inhibitor CA074 [80] . Six different mutants were identified that conferred Cathepsin B independence. Many of these mutations sit at the interface of GP 1 and GP 2 and the selected mutations were thought.....
Document: These observations were confirmed in Vero cells in a recent study by Wong et al. [80] . This group also extended the finding by selecting an infectious, recombinant VSV encoding EBOV GP over several passages to become resistant to the Cathepsin B inhibitor CA074 [80] . Six different mutants were identified that conferred Cathepsin B independence. Many of these mutations sit at the interface of GP 1 and GP 2 and the selected mutations were thought to alter the GP structure such that enhanced proteolysis by one or more currently undefined cysteine proteases was possible. Thus, while Cathepsin B and L independence can be achieved by filoviruses, processing by one or more additional cysteine proteases is still required for production of the fusion-ready form.
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