Author: Huang, Nan-Chieh; Hung, Wan-Ting; Tsai, Wei-Lun; Lai, Feng-Yi; Lin, You-Sheng; Huang, Mei-Shu; Chen, Jih-Jung; Lin, Wei-Yu; Weng, Jing-Ru; Chang, Tsung-Hsien
Title: Ficus septica plant extracts for treating Dengue virus in vitro Document date: 2017_6_8
ID: 1a3cmi9i_17
Snippet: We aimed to reveal a medicinal plant candidate against DENV. We extracted 70 different crude compounds from materials of 24 plants. DENV-caused respiratory disease was revealed (Rodrigues et al., 2014; Wang et al., 2007) , in addition, our previous study showed that the lung carcinoma A549 cells were well susceptible target cells for DENV, these cells have been used in the study model of viral-host interaction. Thus, A549 cells were applied as th.....
Document: We aimed to reveal a medicinal plant candidate against DENV. We extracted 70 different crude compounds from materials of 24 plants. DENV-caused respiratory disease was revealed (Rodrigues et al., 2014; Wang et al., 2007) , in addition, our previous study showed that the lung carcinoma A549 cells were well susceptible target cells for DENV, these cells have been used in the study model of viral-host interaction. Thus, A549 cells were applied as the screening model in this study (Chang, Liao & Lin, 2006) . The cytotoxic effect of the extracts was evaluated in lung carcinoma A549 cells by WST-1 cell proliferation assay. Except S. divaricatus, extracts from other 23 plants revealed no cytotoxicity effect at the maximum tested concentration, 100 µg/ml. Therefore, S. divaricatus extracts were excluded in the antiviral screening (Supplementary information, Table S1 ). (Table 1 ). In addition, leaf extracts of F. sarmentosa var. henryi showed an anti-DENV-2 effect, with IC 50 72.04±14.5 µg/ml, which was higher than for the extracts of F. septica (Table 1 ).
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