Selected article for: "clinical isolate and laboratory strain"
Author: Funaro, Ada; Gribaudo, Giorgio; Luganini, Anna; Ortolan, Erika; Lo Buono, Nicola; Vicenzi, Elisa; Cassetta, Luca; Landolfo, Santo; Buick, Richard; Falciola, Luca; Murphy, Marianne; Garotta, Gianni; Malavasi, Fabio
Title: Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells
  • Document date: 2008_11_12
    • ID: 1u2fkwx3_16
    Snippet: All of the antibodies neutralized the infectivity of the HCMV AD169 laboratory strain in human HELF as well as that of the VR1814 clinical isolate in human umbilical vein endothelial cells (HUVEC), indicating that they are neither strain nor cell-specific. Lastly, none of the antibodies bound the HELF or HUVEC (data not shown). The specificity of the HCMV neutralizing activity was confirmed by the lack of significant neutralization of herpes simp.....
    Document: All of the antibodies neutralized the infectivity of the HCMV AD169 laboratory strain in human HELF as well as that of the VR1814 clinical isolate in human umbilical vein endothelial cells (HUVEC), indicating that they are neither strain nor cell-specific. Lastly, none of the antibodies bound the HELF or HUVEC (data not shown). The specificity of the HCMV neutralizing activity was confirmed by the lack of significant neutralization of herpes simplex virus (HSV)-1 in Vero cells (data not shown).

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