Author: Brauburger, Kristina; Hume, Adam J.; Mühlberger, Elke; Olejnik, Judith
Title: Forty-Five Years of Marburg Virus Research Document date: 2012_10_1
ID: 0hlj6r10_109
Snippet: The VSV-based vaccine expressing MARV GP has also been demonstrated to be effective as a post-exposure treatment. A hundred percent survival of NHPs was observed when the vaccine was administered 20 to 30 minutes after MARV infection [266] . Delaying the time before treatment results in incomplete protection, although five of six animals or two of six animals still survived when given the treatment 1 or 2 days after MARV exposure, respectively [2.....
Document: The VSV-based vaccine expressing MARV GP has also been demonstrated to be effective as a post-exposure treatment. A hundred percent survival of NHPs was observed when the vaccine was administered 20 to 30 minutes after MARV infection [266] . Delaying the time before treatment results in incomplete protection, although five of six animals or two of six animals still survived when given the treatment 1 or 2 days after MARV exposure, respectively [205] . These post-exposure treatments may be useful to prevent disease after known exposure to MARV, such as a laboratory accident, but the effective time frame during an outbreak might be too short and alternatives are needed.
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