Author: Hunt, Catherine L.; Lennemann, Nicholas J.; Maury, Wendy
Title: Filovirus Entry: A Novelty in the Viral Fusion World Document date: 2012_2_7
ID: 1j9zmuub_43
Snippet: Following insertion of EBOV GP 2 fusion loop into the host membrane, the EBOV GP 2 trimeric heptad repeats collapse and form a six-helix bundle containing three HR1 and HR2 domains. The collapse into a coiled coil structure draws the two membranes into proximity allowing partial fusion (hemifusion) of the viral membrane and the host endosomal membrane [8, 9] . Hemifusion eventually leads to complete fusion of the viral and host endosomal membrane.....
Document: Following insertion of EBOV GP 2 fusion loop into the host membrane, the EBOV GP 2 trimeric heptad repeats collapse and form a six-helix bundle containing three HR1 and HR2 domains. The collapse into a coiled coil structure draws the two membranes into proximity allowing partial fusion (hemifusion) of the viral membrane and the host endosomal membrane [8, 9] . Hemifusion eventually leads to complete fusion of the viral and host endosomal membranes, and an opening through which the viral RNA and its associated proteins can be released into the host cell cytoplasm, where the viral life cycle continues.
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