Selected article for: "Ii chain and protein Ii chain"
Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy
  • Document date: 2020_2_27
    • ID: egntml7e_69
    Snippet: The above results showed that autophagy contributes to AS's effect. Thirdly, the influence of AS on autophagy-related molecules was further investigated herein. The markers such as the conversion of microtubule associated protein 1 light chain 3 (LC3B-I) (18 kDa) to LC3B-II (16 kDa) and the accumulation of ATG5 were selected to evaluated autophagy activity (Schaaf, Keulers, Vooijs & Rouschop, 2016) . The results showed that LPS treatment increase.....
    Document: The above results showed that autophagy contributes to AS's effect. Thirdly, the influence of AS on autophagy-related molecules was further investigated herein. The markers such as the conversion of microtubule associated protein 1 light chain 3 (LC3B-I) (18 kDa) to LC3B-II (16 kDa) and the accumulation of ATG5 were selected to evaluated autophagy activity (Schaaf, Keulers, Vooijs & Rouschop, 2016) . The results showed that LPS treatment increased LC3B-II and ATG5 in a dose-dependent manner (Figure 5e1) , consistent with the results that LPS induced pro-inflammatory cytokines release in a dose-dependent manner ( Figure 2a ). This further indicated that LPS-induced cytokine release is autophagy involved.

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