Author: Brauburger, Kristina; Hume, Adam J.; Mühlberger, Elke; Olejnik, Judith
Title: Forty-Five Years of Marburg Virus Research Document date: 2012_10_1
ID: 0hlj6r10_85
Snippet: In late stages of infection MARV particles can be isolated from nearly every organ [12, 14, 130, 194, 208] . Despite high viral load and necrotic lesions, only minor inflammation is observed in infected tissues and organs, indicating a dysregulated immune response [8, 14, 41, 194] . Strong liver pathology is observed, including increased serum activity of liver enzymes. This might influence synthesis of clotting factors and contribute to the obse.....
Document: In late stages of infection MARV particles can be isolated from nearly every organ [12, 14, 130, 194, 208] . Despite high viral load and necrotic lesions, only minor inflammation is observed in infected tissues and organs, indicating a dysregulated immune response [8, 14, 41, 194] . Strong liver pathology is observed, including increased serum activity of liver enzymes. This might influence synthesis of clotting factors and contribute to the observed coagulation defects in MVD [12, 41, 130, 194] . These factors together with systemic virus replication and associated pathology probably trigger the multiorgan failure associated with fatal cases.
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